2，4，6-三硝基苯磺酸诱导雏鸡溃疡性结肠炎模型的建立

doi:10.11843/j.issn.0366-6964.2015.09.027

Abstract

Abstract:

In order to explore the mechanisms of ulcerative colitis in animals and its impact on body，10-day-old SPF chicks were used to build 2，4，6-trinitrobenzene sulfonic acid(TNBS) -induced model by clystering with TNBS in dose of 50，100，and 150 mg•kg^-1，diluting with 50% ethanol，that can help us to analyzes the dose effect of TNBS-induced ulcerative colitis.Further observation and testing about the changes of the chicks’ clinical symptoms，pathology and body weight showed that the ideal medicine dose was 100 mg•kg^-1 of TNBS，which can induce ideal changes of clinical symptoms and pathology in experimental animals without uncontrolled injury and massive death.This study successfully established chicks’ pathological model of ulcerative colitis which laid a foundation for deep research of the development of ulcerative colitis.

CLC Number:

S852.3

YU Zhi-qiang，ZHOU Ying，ZHENG Shi-min. Development of Ulcerative Colitis Models Induced by 2，4，6-trinitrobenzene Sulfonic Acid in Chicks[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(9): 1686-1691.

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Development of Ulcerative Colitis Models Induced by 2，4，6-trinitrobenzene Sulfonic Acid in Chicks

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